MiR-590-5p suppresses hepatocellular carcinoma chemoresistance by targeting YAP1 expression.

ABSTRACT:

Background

Resistance to chemotherapeutic treatment is a common phenomenon in cancers, especially in hepatocellular carcinoma (HCC). The Hippo signaling pathway has been demonstrated to play a role in tumor initiation, development, and progression. However, little is known about its roles in the HCC chemoresistance.

Methods

In this study, real-time PCR and western blotting were used to identify the expression profile of key components of Hippo signaling pathway between chemoresistant and chemosensitive HCC cell lines. In vitro and in vivo loss- and gain-of-function studies were performed to reveal the effects and related mechanism of microRNA-590-5p/YAP1 axis in the chemoresistant phenotype of HCC cells.

Findings

We identified yes-associated protein 1 (YAP1) as the ma

SUBMITTER: Chen M 

PROVIDER: S-EPMC6154877 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature