Linking gut microbiota, metabolic syndrome and economic status based on a population-level analysis.

ABSTRACT:

Background

The metabolic syndrome (MetS) epidemic is associated with economic development, lifestyle transition and dysbiosis of gut microbiota, but these associations are rarely studied at the population scale. Here, we utilised the Guangdong Gut Microbiome Project (GGMP), the largest Eastern population-based gut microbiome dataset covering individuals with different economic statuses, to investigate the relationships between the gut microbiome and host physiology, diet, geography, physical activity and socioeconomic status.

Results

At the population level, 529 OTUs were significantly associated with MetS. OTUs from Proteobacteria and Firmicutes (other than Ruminococcaceae) were mainly positively associated with MetS, whereas those from Bacteroidetes and Ruminococcaceae wer

SUBMITTER: He Y 

PROVIDER: S-EPMC6154942 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature