Brain responses to different types of salience in antipsychotic naive first episode psychosis: An fMRI study.

ABSTRACT: Abnormal salience processing has been suggested to contribute to the formation of positive psychotic symptoms in schizophrenia and related conditions. Previous research utilising reward learning or anticipation paradigms has demonstrated cortical and subcortical abnormalities in people with psychosis, specifically in the prefrontal cortex, the dopaminergic midbrain and the striatum. In these paradigms, reward prediction errors attribute motivational salience to stimuli. However, little is known about possible abnormalities across different forms of salience processing in psychosis patients, and whether any such abnormalities involve the dopaminergic midbrain. The aim of our study was, therefore, to investigate possible alterations in psychosis in neural activity in response to various form

SUBMITTER: Knolle F 

PROVIDER: S-EPMC6154975 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature