Magnetic Force-driven in Situ Selective Intracellular Delivery.

ABSTRACT: Intracellular delivery of functional materials holds great promise in biologic research and therapeutic applications but poses challenges to existing techniques, including the reliance on exogenous vectors and lack of selectivity. To address these problems, we propose a vector-free approach that utilizes millimeter-sized iron rods or spheres driven by magnetic forces to selectively deform targeted cells, which in turn generates transient disruption in cell membranes and enables the delivery of foreign materials into cytosols. A range of functional materials with the size from a few nanometers to hundreds of nanometers have been successfully delivered into various types of mammalian cells in situ with high efficiency and viability and minimal undesired effects. Mechanistically, material del

SUBMITTER: Wang R 

PROVIDER: S-EPMC6155070 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature