Parkin-dependent regulation of the MCU complex component MICU1.

ABSTRACT: The mitochondrial Ca²⁺ uniporter machinery is a multiprotein complex composed by the Ca²⁺ selective pore-forming subunit, the mitochondrial uniporter (MCU), and accessory proteins, including MICU1, MICU2 and EMRE. Their concerted action is required to fine-tune the uptake of Ca²⁺ into the mitochondrial matrix which both sustains cell bioenergetics and regulates the apoptotic response. To adequately fulfil such requirements and avoid impairment in mitochondrial Ca²⁺ handling, the intracellular turnover of all the MCU components must be tightly regulated. Here we show that the MCU complex regulator MICU1, but not MCU and MICU2, is rapidly and selectively degraded by the Ubiquitin Proteasome System (UPS). Moreover, we show that the multifunctional E

SUBMITTER: Matteucci A 

PROVIDER: S-EPMC6155109 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature