Malic Enzyme 1 (ME1) is pro-oncogenic in Apc^Min/+ mice.

ABSTRACT: Cytosolic Malic Enzyme (ME1) provides reduced NADP for anabolism and maintenance of redox status. To examine the role of ME1 in tumor genesis of the gastrointestinal tract, we crossed mice having augmented intestinal epithelial expression of ME1 (ME1-Tg mice) with Apc^Min/+ mice to obtain male Apc^Min/+/ME1-Tg mice. ME1 protein levels were significantly greater within gut epithelium and adenomas of male Apc^Min/+/ME1-Tg than Apc^Min/+ mice. Male Apc^Min/+/ME1-Tg mice had larger and greater numbers of adenomas in the small intestine (jejunum and ileum) than male Apc^Min/+ mice. Male Apc^Min/+/ME1-Tg mice exhibited greater small intestine crypt depth and villus length in non-adenoma regions, correspondent with increased KL

SUBMITTER: Fernandes LM 

PROVIDER: S-EPMC6155149 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature