A new ESI-LC/MS approach for comprehensive metabolic profiling of phytocannabinoids in Cannabis.

ABSTRACT: Most clinical studies of Cannabis today focus on the contents of two phytocannabinoids: (-)-Δ⁹-trans-tetrahydrocannabinol (Δ⁹-THC) and cannabidiol (CBD), regardless of the fact that the plant contains over 100 additional phytocannabinoids whose therapeutic effects and interplay have not yet been fully elucidated. This narrow view of a complex Cannabis plant is insufficient to comprehend the medicinal and pharmacological effects of the whole plant. In this study we suggest a new ESI-LC/MS/MS approach to identify phytocannabinoids from 10 different subclasses, and comprehensively profile the identified compounds in diverse medical Cannabis plants. Overall, 94 phytocannabinoids were identified and used for profiling 36 of the most commonly used Cannabis plants prescribed

SUBMITTER: Berman P 

PROVIDER: S-EPMC6155167 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature