Complexing Methylene Blue with Phosphorus Dendrimers to Increase Photodynamic Activity.

ABSTRACT: The efficiency of photodynamic therapy is limited mainly due to low selectivity, unfavorable biodistribution of photosensitizers, and long-lasting skin sensitivity to light. However, drug delivery systems based on nanoparticles may overcome the limitations mentioned above. Among others, dendrimers are particularly attractive as carriers, because of their globular architecture and high loading capacity. The goal of the study was to check whether an anionic phosphorus dendrimer is suitable as a carrier of a photosensitizer-methylene blue (MB). As a biological model, basal cell carcinoma cell lines were used. We checked the influence of the MB complexation on its singlet oxygen production ability using a commercial fluorescence probe. Next, cellular uptake, phototoxicity, reactive oxygen spec

SUBMITTER: Dabrzalska M 

PROVIDER: S-EPMC6155338 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature