Positive selection in coding regions and motif duplication in regulatory regions of bottlenose dolphin MHC class II genes.

ABSTRACT: The vertebrate immune response is mediated through highly adaptive, quickly evolving cell surface receptors, the major histocompatibility complex (MHC). MHC molecules bind and present a diverse array of pathogenic molecules and trigger a cascade of defenses. Use of MHC variation as a marker for population health has also evolved quickly following advances in sequencing methods. We applied a combination of traditional and next generation sequencing methodology to characterize coding (peptide binding region) and regulatory (proximal promoter) sequence variation in MHC Class II DQA and DQB genes between estuarine and coastal populations of the bottlenose dolphin, Tursiops truncatus, an apex predator whose health status is indicative of anthropogenic impacts on the ecosystem. The coding region

SUBMITTER: Pagan HJT 

PROVIDER: S-EPMC6155461 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature