Integrative proteomics and bioinformatic prediction enable a high-confidence apicoplast proteome in malaria parasites.

ABSTRACT: Malaria parasites (Plasmodium spp.) and related apicomplexan pathogens contain a nonphotosynthetic plastid called the apicoplast. Derived from an unusual secondary eukaryote-eukaryote endosymbiosis, the apicoplast is a fascinating organelle whose function and biogenesis rely on a complex amalgamation of bacterial and algal pathways. Because these pathways are distinct from the human host, the apicoplast is an excellent source of novel antimalarial targets. Despite its biomedical importance and evolutionary significance, the absence of a reliable apicoplast proteome has limited most studies to the handful of pathways identified by homology to bacteria or primary chloroplasts, precluding our ability to study the most novel apicoplast pathways. Here, we combine proximity biotinylation-based p

SUBMITTER: Boucher MJ 

PROVIDER: S-EPMC6155542 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature