Development and Validation of a Clinical Score for Cardiovascular Risk Stratification of Long-Term Childhood Cancer Survivors.

ABSTRACT:

Background

Long-term childhood cancer survivors (CCS) are at increased risk of adverse cardiovascular events; however, there is a paucity of risk-stratification tools to identify those at higher-than-normal risk.

Subjects, materials, and methods

This was a population-based study using data from the Surveillance, Epidemiology, and End Results Program (1973-2013). Long-term CCS (age at diagnosis ≤19 years, survival ≥5 years) were followed up over a median time period of 12.3 (5-40.9) years. Independent predictors of cardiovascular mortality (CVM) were combined into a risk score, which was developed in a derivation set (n = 22,374), and validated in separate patient registries (n = 6,437).

Results

In the derivation registries, older age at diagnosis (≥10 ye

SUBMITTER: Oikonomou EK 

PROVIDER: S-EPMC6156177 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature