Human hippocampal replay during rest prioritizes weakly learned information and predicts memory performance.

ABSTRACT: The hippocampus replays experiences during quiet rest periods, and this replay benefits subsequent memory. A critical open question is how memories are prioritized for this replay. We used functional magnetic resonance imaging (fMRI) pattern analysis to track item-level replay in the hippocampus during an awake rest period after participants studied 15 objects and completed a memory test. Objects that were remembered less well were replayed more during the subsequent rest period, suggesting a prioritization process in which weaker memories-memories most vulnerable to forgetting-are selected for replay. In a second session 12 hours later, more replay of an object during a rest period predicted better subsequent memory for that object. Replay predicted memory improvement across sessions only

SUBMITTER: Schapiro AC 

PROVIDER: S-EPMC6156217 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature