Persister Cells - a Plausible Outcome of Neutral Coevolutionary Drift.

ABSTRACT: The phenomenon of bacterial persistence - a non-inherited antibiotic tolerance in a minute fraction of the bacterial population, was observed more than 70 years ago. Nowadays, it is suggested that "persister cells" undergo an alternative scenario of the cell cycle; however, pathways involved in its emergence are still not identified. We present a mathematically grounded scenario of such possibility. We have determined that population drift in the space of multiple neutrally coupled mutations, which we called "neutrally coupled co-evolution" (NCCE), leads to increased dynamic complexity of bacterial populations via appearance of cells capable of carrying out a single cell cycle in two or more alternative ways and that universal properties of the coupled transcription-translation system unde

SUBMITTER: Khlebodarova TM 

PROVIDER: S-EPMC6156226 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature