Low-density lipoprotein receptor-related protein 6 regulates alternative pre-mRNA splicing.

ABSTRACT: Low-density lipoprotein receptor-related protein 6 (LRP6) serves as a Wnt coreceptor. Although Wnt/LRP6 signalling is best known for the β-catenin-dependent regulation of target genes in tissue development and homeostasis, emerging evidence demonstrates the biological aspects of LRP6 beyond a Wnt coreceptor. Whether LRP6 modulates tissue development in a Wnt/β-catenin signalling-independent manner remains unknown. Using a model of striated muscle development, we observed that LRP6 was almost undetectable in proliferating myoblasts, whereas its expression gradually increased in the nucleus of myodifferentiating cells. During myodifferentiation, LRP6 modulated the muscle-specific splicing of integrin-β1D and consequent myotube maturation independently of the β-catenin-dependent Wnt signallin

SUBMITTER: Yuan T 

PROVIDER: S-EPMC6156287 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature