Peroxisome Proliferator Activated Receptor Agonists Modulate Transposable Element Expression in Brain and Liver.

ABSTRACT: Peroxisome proliferator activated receptors (PPARs) are nuclear hormone receptors that act as transcription factors in response to endogenous lipid messengers. The fibrates and thiazolidinediones are synthetic PPAR agonists used clinically to treat dyslipidemia and Type 2 Diabetes Mellitus, respectively, but also improve symptoms of several other diseases. Transposable elements (TEs), repetitive sequences in mammalian genomes, are implicated in many of the same conditions for which PPAR agonists are therapeutic, including neurodegeneration, schizophrenia, and drug addiction. We tested the hypothesis that there is a link between actions of PPAR agonists and TE expression. We developed an innovative application of microarray data by mapping Illumina mouse WG-6 microarray probes to areas of t

SUBMITTER: Ferguson LB 

PROVIDER: S-EPMC6156381 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature