Systems pathology analysis identifies neurodegenerative nature of age-related vitreoretinal interface diseases.

ABSTRACT: Aging is a phenomenon that is associated with profound medical implications. Idiopathic epiretinal membrane (iEMR) and macular hole (MH) are the major vision-threatening vitreoretinal diseases affecting millions of aging people globally, making these conditions an important public health issue. iERM is characterized by fibrous tissue developing on the surface of the macula, which leads to biomechanical and biochemical macular damage. MH is a small breakage in the macula and is associated with many ocular conditions. Although several individual factors and pathways are suggested, a systems pathology level understanding of the molecular mechanisms underlying these disorders is lacking. Therefore, we performed mass spectrometry-based label-free quantitative proteomics analysis of the vitreous

SUBMITTER: Ohman T 

PROVIDER: S-EPMC6156470 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature