VCAM-1 upregulation accompanies muscle remodeling following resistance-type exercise in Snell dwarf (Pit1^dw/dw ) mice.

ABSTRACT: Snell dwarf mice (Pit1^dw/dw ) exhibit deficiencies in growth hormone, prolactin, and thyroid stimulating hormone. Besides being an experimental model of hypopituitarism, these mice are long-lived (>40% lifespan extension) and utilized as a model of slowed/delayed aging. Whether this longevity is accompanied by a compromised quality of life in terms of muscular performance has not yet been characterized. In this study, we investigated nontrained and trained muscles 1 month following a general validated resistance-type exercise protocol in 3-month-old Snell dwarf mice and control littermates. Nontrained Snell dwarf gastrocnemius muscles exhibited a 1.3-fold greater muscle mass to body weight ratio than control values although muscle quality, maximum isometric torque normalized to

SUBMITTER: Rader EP 

PROVIDER: S-EPMC6156491 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature