Anxa4 mediated airway progenitor cell migration promotes distal epithelial cell fate specification.

ABSTRACT: Genetic studies have shown that FGF10/FGFR2 signaling is required for airway branching morphogenesis and FGF10 functions as a chemoattractant factor for distal epithelial cells during lung development. However, the detail downstream cellular and molecular mechanisms have not been fully characterized. Using live imaging of ex vivo cultured lungs, we found that tip airway epithelial progenitor cells migrate faster than cleft cells during airway bud formation and this migration process is controlled by FGFR2-mediated ERK1/2 signaling. Additionally, we found that airway progenitor cells that migrate faster tend to become distal airway progenitor cells. We identified that Anxa4 is a downstream target of ERK1/2 signaling. Anxa4^-/- airway epithelial cells exhibit a "lag-behind" behavio

SUBMITTER: Jiang K 

PROVIDER: S-EPMC6156511 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature