Aging is associated with increased FGF21 levels but unaltered FGF21 responsiveness in adipose tissue.

ABSTRACT: Fibroblast growth factor 21 (FGF21) has been proposed to be an antiaging hormone on the basis of experimental studies in rodent models. However, circulating FGF21 levels are increased with aging in rodents and humans. Moreover, despite the metabolic health-promoting effects of FGF21, the levels of this hormone are increased under conditions such as obesity and diabetes, an apparent incongruity that has been attributed to altered tissue responsiveness to FGF21. Here, we investigated serum FGF21 levels and expression of genes encoding components of the FGF21-response molecular machinery in adipose tissue from healthy elderly individuals (≥70 years old) and young controls. Serum FGF21 levels were increased in elderly individuals and were positively correlated with insulinemia and HOMA-IR, ind

SUBMITTER: Villarroya J 

PROVIDER: S-EPMC6156525 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature