Gene expression-based drug repurposing to target aging.

ABSTRACT: Aging is the largest risk factor for a variety of noncommunicable diseases. Model organism studies have shown that genetic and chemical perturbations can extend both lifespan and healthspan. Aging is a complex process, with parallel and interacting mechanisms contributing to its aetiology, posing a challenge for the discovery of new pharmacological candidates to ameliorate its effects. In this study, instead of a target-centric approach, we adopt a systems level drug repurposing methodology to discover drugs that could combat aging in human brain. Using multiple gene expression data sets from brain tissue, taken from patients of different ages, we first identified the expression changes that characterize aging. Then, we compared these changes in gene expression with drug-perturbed expressi

SUBMITTER: Donertas HM 

PROVIDER: S-EPMC6156541 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature