Types of naming errors in chronic post-stroke aphasia are dissociated by dual stream axonal loss.

ABSTRACT: The types of errors during speech production can vary across individuals with chronic post-stroke aphasia, possibly due to the location and extent of brain damage. In this study, we evaluated the relationship between semantic vs. phonemic errors during confrontational naming, and their relationship with the degree of damage to ventral and dorsal white matter pathways extending beyond the necrotic stroke lesion. Based on the dual stream model of language processing, we tested the hypothesis that semantic errors would be associated with ventral stream damage, whereas phonemic errors would be associated with dorsal stream damage, but not vice-versa. Multi-shell diffusion MRI was used to obtain kurtosis-based white matter tractography from 32 chronic stroke survivors. Using diffusion microstru

SUBMITTER: McKinnon ET 

PROVIDER: S-EPMC6156587 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature