Dynamic force spectroscopy of synthetic oligorotaxane foldamers.

ABSTRACT: Wholly synthetic molecules involving both mechanical bonds and a folded secondary structure are one of the most promising architectures for the design of functional molecular machines with unprecedented properties. Here, we report dynamic single-molecule force spectroscopy experiments that explore the energetic details of donor-acceptor oligorotaxane foldamers, a class of molecular switches. The mechanical breaking of the donor-acceptor interactions responsible for the folded structure shows a high constant rupture force over a broad range of loading rates, covering three orders of magnitude. In comparison with dynamic force spectroscopy performed during the past 20 y on various (bio)molecules, the near-equilibrium regime of oligorotaxanes persists at much higher loading rates, at which bi

SUBMITTER: Sluysmans D 

PROVIDER: S-EPMC6156609 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature