Lack of Sprouty 1 and 2 enhances survival of effector CD8⁺ T cells and yields more protective memory cells.

ABSTRACT: Identifying novel pathways that promote robust function and longevity of cytotoxic T cells has promising potential for immunotherapeutic strategies to combat cancer and chronic infections. We show that sprouty 1 and 2 (Spry1/2) molecules regulate the survival and function of memory CD8⁺ T cells. Spry1/2 double-knockout (DKO) ovalbumin (OVA)-specific CD8⁺ T cells (OT-I cells) mounted more vigorous autoimmune diabetes than WT OT-I cells when transferred to mice expressing OVA in their pancreatic β-islets. To determine the consequence of Spry1/2 deletion on effector and memory CD8⁺ T cell development and function, we used systemic infection with lymphocytic choriomeningitis virus (LCMV) Armstrong. Spry1/2 DKO LCMV gp33-specific P14 CD8⁺ T cells surv

SUBMITTER: Shehata HM 

PROVIDER: S-EPMC6156615 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature