Remote electrochemical modulation of pK_a in a rotaxane by co-conformational allostery.

ABSTRACT: Allosteric control, one of Nature's most effective ways to regulate functions in biomolecular machinery, involves the transfer of information between distant sites. The mechanistic details of such a transfer are still an object of intensive investigation and debate, and the idea that intramolecular communication could be enabled by dynamic processes is gaining attention as a complement to traditional explanations. Mechanically interlocked molecules, owing to the particular kind of connection between their components and the resulting dynamic behavior, are attractive systems to investigate allosteric mechanisms and exploit them to develop functionalities with artificial species. We show that the pK_a of an ammonium site located on the axle component of a [2]rotaxane can be reversi

SUBMITTER: Ragazzon G 

PROVIDER: S-EPMC6156658 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature