Importance of endoscopic and histological evaluation in the management of immune checkpoint inhibitor-induced colitis.

ABSTRACT:

Background

Immune checkpoint inhibitors (ICPI) are efficacious treatments for advanced malignancies but can result in immune mediated diarrhea and colitis (IDC). Currently, the guidelines for the treatment of IDC depend only on clinical symptoms. Endoscopic and histologic features of such adverse events are not well studied in a manner that can help to gauge treatment plans. We aimed to characterize endoscopic and histologic features of IDC and to assess their association with clinical outcomes.

Methods

Our study included patients who had undergone endoscopy for IDC (1/2010 to 3/2018). Patients with GI infection at time of onset were excluded. High-risk endoscopic features were ulcers deeper than 2 mm, larger than 1 cm, and extensive colonic involvement. Univariate and multi

SUBMITTER: Abu-Sbeih H 

PROVIDER: S-EPMC6156850 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature