Treating endothelial dysfunction with vitamin D in chronic kidney disease: a meta-analysis.

ABSTRACT:

Background

Vitamin D deficiency is common in patients with chronic kidney disease (CKD), and is associated with endothelial dysfunction and cardiovascular disease. We performed a meta-analysis to assess the effect of vitamin D treatment on flow mediated vasodilation (FMD) in CKD patients.

Methods

PubMed/Medline, Web of Science, Embase and Cochrane trials and reviews were searched systematically for randomized controlled trials (RCT:s) using any vitamin D compound, at any stage of CKD, with FMD as outcome. Fixed and random effects models were performed using the standardized mean difference effect size post treatment for each trial. Heterogeneity was assessed by I² statistics.

Results

4 trials were included, comprising 305 patients. One used both 1 and 2 μg

SUBMITTER: Lundwall K 

PROVIDER: S-EPMC6156877 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature