Impaired bone marrow B-cell development in mice with a bronchiolitis obliterans model of cGVHD.

ABSTRACT: Chronic graft-versus-host disease (cGVHD) causes significant morbidity and mortality in patients after allogeneic bone marrow (BM) or stem cell transplantation (allo-SCT). Recent work has indicated that both T and B lymphocytes play an important role in the pathophysiology of cGVHD. Previously, our group showed a critical role for the germinal center response in the function of B cells using a bronchiolitis obliterans (BO) model of cGVHD. Here, we demonstrated for the first time that cGVHD is associated with severe defects in the generation of BM B lymphoid and uncommitted common lymphoid progenitor cells. We found an increase in the number of donor CD4⁺ T cells in the BM of mice with cGVHD that was negatively correlated with B-cell development and the frequency of osteoblasts a

SUBMITTER: Kolupaev OV 

PROVIDER: S-EPMC6156893 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature