Delineating the Macroscale Areal Organization of the Macaque Cortex In Vivo.

ABSTRACT: Complementing long-standing traditions centered on histology, fMRI approaches are rapidly maturing in delineating brain areal organization at the macroscale. The non-human primate (NHP) provides the opportunity to overcome critical barriers in translational research. Here, we establish the data requirements for achieving reproducible and internally valid parcellations in individuals. We demonstrate that functional boundaries serve as a functional fingerprint of the individual animals and can be achieved under anesthesia or awake conditions (rest, naturalistic viewing), though differences between awake and anesthetized states precluded the detection of individual differences across states. Comparison of awake and anesthetized states suggested a more nuanced picture of changes in connectivit

SUBMITTER: Xu T 

PROVIDER: S-EPMC6157013 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature