Applying graph theory to protein structures: an Atlas of coiled coils.

ABSTRACT:

Motivation

To understand protein structure, folding and function fully and to design proteins de novo reliably, we must learn from natural protein structures that have been characterized experimentally. The number of protein structures available is large and growing exponentially, which makes this task challenging. Indeed, computational resources are becoming increasingly important for classifying and analyzing this resource. Here, we use tools from graph theory to define an Atlas classification scheme for automatically categorizing certain protein substructures.

Results

Focusing on the α-helical coiled coils, which are ubiquitous protein-structure and protein-protein interaction motifs, we present a suite of computational resources designed for analyzing these assemblies. i

SUBMITTER: Heal JW 

PROVIDER: S-EPMC6157074 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature