Radiation-Mediated Tumor Growth Inhibition Is Significantly Enhanced with Redox-Active Compounds That Cycle with Ascorbate.

ABSTRACT:

Aims

We aim here to demonstrate that radiation (RT) enhances tumor sensitization by only those Mn complexes that are redox active and cycle with ascorbate (Asc), thereby producing H₂O₂ and utilizing it subsequently in protein S-glutathionylation in a glutathione peroxidase (GPx)-like manner. In turn, such compounds affect cellular redox environment, described by glutathione disulfide (GSSG)/glutathione (GSH) ratio, and tumor growth. To achieve our goal, we tested several Mn complexes of different chemical and physical properties in cellular and animal flank models of 4T1 breast cancer cell. Four other cancer cell lines were used to substantiate key findings.

Results

Joint administration of cationic Mn porphyrin (MnP)-based redox active compounds, MnTE-2

SUBMITTER: Tovmasyan A 

PROVIDER: S-EPMC6157436 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature