Increased risk of aortic aneurysm and dissection in patients with Sjogren's syndrome: a nationwide population-based cohort study in Taiwan.

ABSTRACT:

Objectives

Sjögren's syndrome (SS) is a systemic autoimmune disorder. Several molecular pathways and the activation of matrix metalloproteinases associated with the pathogenesis of SS participate in the initiation and progression of aortic aneurysm (AA) and aortic dissection (AD). In this study, we aimed to evaluate whether patients with SS exhibit an increased risk of AA or AD.

Methods

We conducted a retrospective cohort study using a database extracted from Taiwan's National Health Insurance Research Database. All medical conditions for each case and control were categorised using the International Classification of Diseases, Ninth Revision. HRs and 95% CIs for associations between SS and AA/AD were estimated using Cox regression and adjusted for comorbidities.

Results<

SUBMITTER: Tsai YD 

PROVIDER: S-EPMC6157519 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature