Metabolic syndrome and extensive adipose tissue inflammation in morbidly obese Gottingen minipigs.

ABSTRACT:

Objective

The worldwide prevalence of obesity has increased to 10% in men and 15% in women and is associated with severe comorbidities such as diabetes, cancer, and cardiovascular disease. Animal models of obesity are central to experimental studies of disease mechanisms and therapeutic strategies. Diet-induced obesity (DIO) models in rodents have provided important insights into the pathophysiology of obesity and, in most instances, are the first in line for exploratory pharmacology studies. To deepen the relevance towards translation to human patients, we established a corresponding DIO model in Göttingen minipigs (GM).

Methods

Young adult female ovariectomized GM were fed a high-fat/high-energy diet for a period of 70 weeks. The ration was calculated to meet the requireme

SUBMITTER: Renner S 

PROVIDER: S-EPMC6157610 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature