Maternal exercise intervention in obese pregnancy improves the cardiovascular health of the adult male offspring.

ABSTRACT:

Objective

Obesity during pregnancy is associated with an elevated risk of cardiovascular disease in the offspring. With increased numbers of women entering pregnancy overweight or obese, there is a requirement for targeted interventions to reduce disease risk in future generations. Using an established murine model of maternal obesity during pregnancy, we investigated if a treadmill exercise intervention in the mother could improve offspring cardiac health and explored potential underlying mechanisms.

Methods

A 20-minute treadmill exercise intervention protocol was performed 5 days a week in diet-induced obese female C57BL/6 mice 1 week prior to, and up to E17 of pregnancy. All male offspring were weaned onto a control diet and studied at 8 weeks of age when their cardiovasc

SUBMITTER: Beeson JH 

PROVIDER: S-EPMC6157615 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature