Independent association of HLA-DPB1*02:01 with rheumatoid arthritis in Japanese populations.

ABSTRACT:

Objective

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized with joint destructions; environmental and genetic factors were thought to be involved in the etiology of RA. The production of anti-citrullinated peptide antibodies (ACPA) is specifically associated with RA. DRB1 is associated with the susceptibility of RA, especially ACPA-positive RA [ACPA(+)RA]. However, a few studies reported on the independent associations of DPB1 alleles with RA susceptibility. Thus, we investigated the independent association of DPB1 alleles with RA in Japanese populations.

Methods

Association analyses of DPB1 were conducted by logistic regression analysis in 1667 RA patients and 413 controls.

Results

In unconditioned analysis, DPB1*04:02 was nominally associated

SUBMITTER: Furukawa H 

PROVIDER: S-EPMC6157818 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature