Salmonella stimulates pro-inflammatory signalling through p21-activated kinases bypassing innate immune receptors.

ABSTRACT: Microbial infections are most often countered by inflammatory responses that are initiated through the recognition of conserved microbial products by innate immune receptors and result in pathogen expulsion^1-6. However, inflammation can also lead to pathology. Tissues such as the intestinal epithelium, which are exposed to microbial products, are therefore subject to stringent negative regulatory mechanisms to prevent signalling through innate immune receptors^6-11. This presents a challenge to the enteric pathogen Salmonella Typhimurium, which requires intestinal inflammation to compete against the resident microbiota and to acquire the nutrients and electron acceptors that sustain its replication^12,13. We show here that S. Typhimurium stimulates pro-inflam

SUBMITTER: Sun H 

PROVIDER: S-EPMC6158040 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature