Increasing SBP variability is associated with an increased risk of developing incident diabetic foot ulcers.

ABSTRACT: OBJECTIVE:SBP variability may be a target for mitigating end-organ damage associated with vascular disease. We evaluated the relationship between increased SBP variability and risk of incident diabetic foot ulceration. METHODS:Using a nested case-control design, we followed patients diagnosed with diabetes and treated within the US Department of Veterans Affairs Healthcare system for development of a diabetic foot ulcer (event) between 2006 and 2010. Each case was randomly matched to up to five controls based on age, sex, race/ethnicity, and calendar time. SBP variability was computed using at least three blood pressure measurements from the year preceding the event. The association between SBP variability and foot ulceration was examined using conditional logistic regression. Potential pr

SUBMITTER: Brennan MB 

PROVIDER: S-EPMC6158046 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature