EXP2 is a nutrient-permeable channel in the vacuolar membrane of Plasmodium and is essential for protein export via PTEX.

ABSTRACT: Intraerythrocytic malaria parasites reside within a parasitophorous vacuolar membrane (PVM) generated during host cell invasion¹. Erythrocyte remodelling and parasite metabolism require the export of effector proteins and transport of small molecules across this barrier between the parasite surface and host cell cytosol^2,3. Protein export across the PVM is accomplished by the Plasmodium translocon of exported proteins (PTEX) consisting of three core proteins, the AAA+ ATPase HSP101 and two additional proteins known as PTEX150 and EXP2⁴. Inactivation of HSP101 and PTEX150 arrests protein export across the PVM^5,6, but the contribution of EXP2 to parasite biology is not well understood⁷. A nutrient permeable channel in the PVM has also be

SUBMITTER: Garten M 

PROVIDER: S-EPMC6158082 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature