TP53 single nucleotide polymorphism (rs1042522) in Iranian patients with coronary artery disease.

ABSTRACT: Chronic diseases including coronary artery disease (CAD) impose a high burden in terms of mortality and disability particularly in developing countries. Both genetic and environmental risk factors confer susceptibility to CAD. Meanwhile, a functional polymorphism in the tumor protein p53 (TP53) gene (codon 72, exon 4) has been reported to be associated with a wide range of cancers and inflammatory disorders. There are controversies regarding CAD and involvement of the TP53 codon 72 single nucleotide polymorphism; therefore, the present case-control study was conducted to evaluate the potential association between this TP53 polymorphism and CAD in an Iranian population. A total of 153 subjects (including 70 patients diagnosed with CAD and 83 subjects with normal coronary parameters, determi

SUBMITTER: Omrani-Nava V 

PROVIDER: S-EPMC6158393 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature