Effect of Productive Human Papillomavirus 16 Infection on Global Gene Expression in Cervical Epithelium.

ABSTRACT: Human papillomavirus (HPV) infection is the world's most common sexually transmitted infection and is responsible for most cases of cervical cancer. Previous studies of global gene expression changes induced by HPV infection have focused on the cancerous stages of infection, and therefore, not much is known about global gene expression changes at early preneoplastic stages of infection. We show for the first time the global gene expression changes during early-stage HPV16 infection in cervical tissue using 3-dimensional organotypic raft cultures, which produce high levels of progeny virions. cDNA microarray analysis showed that a total of 594 genes were upregulated and 651 genes were downregulated at least 1.5-fold with HPV16 infection. Gene ontology analysis showed that biological process

SUBMITTER: Kang SD 

PROVIDER: S-EPMC6158420 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature