KAP1 facilitates reinstatement of heterochromatin after DNA replication.

ABSTRACT: During cell division, maintenance of chromatin features from the parental genome requires their proper establishment on its newly synthetized copy. The loss of epigenetic marks within heterochromatin, typically enriched in repetitive elements, endangers genome stability and permits chromosomal rearrangements via recombination. However, how histone modifications associated with heterochromatin are maintained across mitosis remains poorly understood. KAP1 is known to act as a scaffold for a repressor complex that mediates local heterochromatin formation, and was previously demonstrated to play an important role during DNA repair. Accordingly, we investigated a putative role for this protein in the replication of heterochromatic regions. We first found that KAP1 associates with several DNA re

SUBMITTER: Jang SM 

PROVIDER: S-EPMC6158507 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature