Bifidobacterial Dominance of the Gut in Early Life and Acquisition of Antimicrobial Resistance.

ABSTRACT: Bifidobacterium species are important commensals capable of dominating the infant gut microbiome, in part by producing acids that suppress growth of other taxa. Bifidobacterium species are less prone to possessing antimicrobial resistance (AMR) genes (ARGs) than other taxa that may colonize infants. Given that AMR is a growing public health crisis and ARGs are present in the gut microbiome of humans from early life, this study examines the correlation between a Bifidobacterium-dominated infant gut microbiome and AMR levels, measured by a culture-independent metagenomic approach both in early life and as infants become toddlers. In general, Bifidobacterium dominance is associated with a significant reduction in AMR in a Bangladeshi cohort, both in the number of a

SUBMITTER: Taft DH 

PROVIDER: S-EPMC6158511 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature