Low-Frequency Blood Group Antigens in Switzerland.

ABSTRACT:

Background

High-frequency blood group antigens (HFA) are present in >90% of the human population, according to some reports even in >99% of individuals. Therefore, patients lacking HFA may become challenging for transfusion support because compatible blood is hardly found, and if the patient carries alloantibodies, the cross-match will be positive with virtual every red cell unit tested.

Methods

In this study, we applied high-throughput blood group SNP genotyping on >37,000 Swiss blood donors, intending to identify homozygous carriers of low-frequency blood group antigens (LFA).

Results

326 such individuals were identified and made available to transfusion specialists for future support of patients in need of rare blood products.

Conclusion

Thorough comparison

SUBMITTER: Gassner C 

PROVIDER: S-EPMC6158591 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature