Transneuronal Downregulation of the Premotor Cholinergic System After Corticospinal Tract Loss.

ABSTRACT: Injury to the supraspinal motor systems, especially the corticospinal tract, leads to movement impairments. In addition to direct disruption of descending motor pathways, spinal motor circuits that are distant to and not directly damaged by the lesion undergo remodeling that contributes significantly to the impairments. Knowing which spinal circuits are remodeled and the underlying mechanisms are critical for understanding the functional changes in the motor pathway and for developing repair strategies. Here, we target spinal premotor cholinergic interneurons (IN) that directly modulate motoneuron excitability via their cholinergic C-bouton terminals. Using a model of unilateral medullary corticospinal tract lesion in male rats, we found transneuronal downregulation of the premotor choline

SUBMITTER: Jiang YQ 

PROVIDER: S-EPMC6158693 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature