Genome wide analyses uncover allele-specific RNA editing in human and mouse.

ABSTRACT: RNA editing is one of the most common RNA level modifications that potentially generate amino acid changes similar to those resulting from genomic nonsynonymous mutations. However, unlike DNA level allele-specific modifications such as DNA methylation, it is currently unknown whether RNA editing displays allele-specificity across tissues and species. Here, we analyzed allele-specific RNA editing in human tissues and from brain tissues of heterozygous mice generated by crosses between divergent mouse strains and found a high proportion of overlap of allele-specific RNA editing sites between different samples. We identified three allele-specific RNA editing sites cause amino acid changes in coding regions of human and mouse genes, whereas their associated SNPs yielded synonymous differences.

SUBMITTER: Zhou ZY 

PROVIDER: S-EPMC6158710 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature