Investigation of the Syncytial Nature of Detrusor Smooth Muscle as a Determinant of Action Potential Shape.

ABSTRACT: Unlike most excitable cells, certain syncytial smooth muscle cells are known to exhibit spontaneous action potentials of varying shapes and sizes. These differences in shape are observed even in electrophysiological recordings obtained from a single cell. The origin and physiological relevance of this phenomenon are currently unclear. The study presented here aims to test the hypothesis that the syncytial nature of the detrusor smooth muscle tissue contributes to the variations in the action potential profile by influencing the superposition of the passive and active signals. Data extracted from experimental recordings have been compared with those obtained through simulations. The feature correlation studies on action potentials obtained from the experimental recordings suggest the underl

SUBMITTER: Appukuttan S 

PROVIDER: S-EPMC6158746 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature