Rapid decline in lung function is temporally associated with greater metabolically active adiposity in a longitudinal study of healthy adults.

ABSTRACT:

Rationale

Adiposity is associated with low lung function, but the longitudinal relationship between lung function and adiposity is inadequately studied.

Objective

To examine the bidirectional longitudinal associations between rapid decline in lung function and adiposity phenotypes in healthy adults.

Methods

This secondary analysis used a 25-year longitudinal dataset from the Coronary Artery Risk Development in Young Adults (CARDIA) study that enrolled 5115 participants.

Measurements

In the first analysis, metabolic syndrome at or before CARDIA year (Y) 10 (Y10) was the predictor, and subsequent rapid decline in forced vital capacity (FVC) or forced expiratory volume in 1 s (FEV₁) between Y10 and Y20 was the outcome. In the second analysis, rapid decl

SUBMITTER: Moualla M 

PROVIDER: S-EPMC6158777 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature