A community-driven reconstruction of the Aspergillus niger metabolic network.

ABSTRACT:

Background

Aspergillus niger is an important fungus used in industrial applications for enzyme and acid production. To enable rational metabolic engineering of the species, available information can be collected and integrated in a genome-scale model to devise strategies for improving its performance as a host organism.

Results

In this paper, we update an existing model of A. niger metabolism to include the information collected from 876 publications, thereby expanding the coverage of the model by 940 reactions, 777 metabolites and 454 genes. In the presented consensus genome-scale model of A. niger iJB1325 , we integrated experimental data from publications and patents, as well as our own experiments, into a consistent network. This information has been

SUBMITTER: Brandl J 

PROVIDER: S-EPMC6158834 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature