Effects of methylprednisolone on blood-brain barrier and cerebral inflammation in cardiac surgery-a randomized trial.

ABSTRACT:

Background

Cognitive dysfunction is a frequent complication to open-heart surgery. Cerebral inflammation caused by blood-brain barrier (BBB) dysfunction due to a systemic inflammatory response is considered a possible etiology. The effects of the glucocorticoid, methylprednisolone, on cerebrospinal fluid (CSF) markers of BBB function, neuroinflammation, and brain injury in patients undergoing cardiac surgery with cardiopulmonary bypass were studied.

Methods

In this prospective, randomized, blinded study, 30 patients scheduled for elective surgical aortic valve replacement were randomized to methylprednisolone 15 mg/kg (n = 15) or placebo (n = 15) as a bolus dose administered after induction of anesthesia. CSF and blood samples were obtained the day before and 24 h after surg

SUBMITTER: Danielson M 

PROVIDER: S-EPMC6158839 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature