Dataset Information
Escher-FBA: a web application for interactive flux balance analysis.
Ontology highlight
ABSTRACT: Background
Flux balance analysis (FBA) is a widely-used method for analyzing metabolic networks. However, most existing tools that implement FBA require downloading software and writing code. Furthermore, FBA generates predictions for metabolic networks with thousands of components, so meaningful changes in FBA solutions can be difficult to identify. These challenges make it difficult for beginners to learn how FBA works.Results
To meet this need, we present Escher-FBA, a web application for interactive FBA simulations within a pathway visualization. Escher-FBA allows users to set flux bounds, knock out reactions, change objective functions, upload metabolic models, and generate high-quality figures without downloading software or writing code. We provide detailed instructions on how to use Escher-FBA to replicate several FBA simulations that generate real scientific hypotheses.Conclusions
We designed Escher-FBA to be as intuitive as possible so that users can quickly and easily understand the core concepts of FBA. The web application can be accessed at https://sbrg.github.io/escher-fba .
SUBMITTER: Rowe E
PROVIDER: S-EPMC6158907 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Publications
Escher-FBA: a web application for interactive flux balance analysis.
BMC systems biology 20180926 1
<h4>Background</h4>Flux balance analysis (FBA) is a widely-used method for analyzing metabolic networks. However, most existing tools that implement FBA require downloading software and writing code. Furthermore, FBA generates predictions for metabolic networks with thousands of components, so meaningful changes in FBA solutions can be difficult to identify. These challenges make it difficult for beginners to learn how FBA works.<h4>Results</h4>To meet this need, we present Escher-FBA, a web app ...[more]