A novel role for calpain in the endothelial dysfunction induced by activation of angiotensin II type 1 receptor signaling.

ABSTRACT:

Rationale

The cytosolic protease calpain has been recently implicated in the vascular remodeling of angiotensin II (Ang II) type 1 receptor (AT(1)R) signaling. The role of Ang II/AT(1)R/calpain signaling on endothelial function, an important and early determinant of vascular pathology, remains though totally unknown. Accordingly, we investigated the role of calpain in the endothelial dysfunction of Ang II.

Objective

To demonstrate a mechanistic role for calpain in the endothelial dysfunction induced by Ang II/AT(1)R signaling. To establish endothelial-expressed calpains as an important target of AT(1)R signaling.

Methods and results

Subchronic administration of nonpressor doses of Ang II to rats and mice significantly increased vascular calpain activity via AT(1)R sig

SUBMITTER: Scalia R 

PROVIDER: S-EPMC6159903 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature